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分子藥理學雜志 欄目熱點
Diketo Hexenoic Acid Derivatives Are Novel Selective Non-Nucleoside Inhibitors of Mammalian Terminal Deoxynucleotidyl Transferases, with Potent Cytotoxic Effe
Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination
Hypoxia-Inducible Factor-1 (HIF-1)
Live Long and Prosper
Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF2 Receptor-Transfected SH-SY5Y Neuroblastoma Cells
Transcriptional Regulation of Mouse eOpioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the eOpioid Receptor Gen
Repression of Human GSTA1 by Interleukin-1 Is Mediated by Variant Hepatic Nuclear Factor-1C
Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases
The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor
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2003年第63卷第1期
Activation of Microsomal Glutathione S-Transferase by Peroxynitrite
All-trans-Retinoic Acid Binds to and Inhibits Adenine Nucleotide Translocase and induces Mitochondrial Permeability Transition
Assessment of the Effect of Phosphorylated Metabolites of Anti-Human Immunodeficiency Virus and Anti-Hepatitis B Virus Pyrimidine Analogs on the Behavior of H
Breast Cancer Resistance Protein (BCRP/ABCG2) Induces Cellular Resistance to HIV-1 Nucleoside Reverse Transcriptase Inhibitors
Bryostatin 1 and UCN-01 Potentiate 1--D-Arabinofuranosylcytosine-Induced Apoptosis in Human Myeloid Leukemia Cells through Disparate Mechanisms
Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
Chemical Synthesis of MT1 and MT7 Muscarinic Toxins: Critical Role of Arg-34 in Their Interaction with M1 Muscarinic Receptor
Cloning, Sequencing and Tissue Distribution of Rat Flavin-Containing Monooxygenase 4: Two Different Forms Are Produced by Tissue-Specific Alternative Splicing
Coexpression of -Opioid Receptors with µ Receptors in GH3 Cells Changes the Functional Response to µ Agonists from Inhibitory to Excitatory
Detection of Thymidylate Synthase Modulators by a Novel Screening Assay
Down-Regulation of Hepatic Nicotine Metabolism and a CYP2A6-Like Enzyme in African Green Monkeys after Long-Term Nicotine Administration
Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene
Growth Inhibition by the Farnesyltransferase Inhibitor FTI-277 Involves Bcl-2 Expression and Defective Association with Raf-1 in Liver Cancer Cell Lines
Key Structural Features of Nonsteroidal Ligands for Binding and Activation of the Androgen Receptor
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2005年第67卷第1期
Multiple Independent Functions of Arrestins in the Regulation of Protease-Activated Receptor-2 Signaling and Trafficking
The Cardiovascular Actions of Protease-Activated Receptors
Multiple Mechanisms Are Involved in Ah Receptor-Mediated Cell Cycle Arrest
Interaction between Cardiac Calsequestrin and Drugs with Known Cardiotoxicity
Estrogen Receptor Activation of Phosphoinositide-3 Kinase, Akt, and Nitric Oxide Signaling in Cerebral Blood Vessels: Rapid and Long-Term Effects
Regulation of P2Y1 Receptor-Mediated Signaling by the Ectonucleoside Triphosphate Diphosphohydrolase Isozymes NTPDase1 and NTPDase2
Structural Basis for Epibatidine Selectivity at Desensitized Nicotinic Receptors
Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by o
Amphetamines Take Two to Tango: an Oligomer-Based Counter-Transport Model of Neurotransmitter Transport Explores the Amphetamine Action
Protein Kinase C-Independent Effects of Protein Kinase D3 in Glucose Transport in L6 Myotubes
Dynamics of Ca2+-Dependent Cl- Channel Modulation by Niflumic Acid in Rabbit Coronary Arterial Myocytes
Down-Regulation Does Not Mediate Natriuretic Peptide-Dependent Desensitization of Natriuretic Peptide Receptor (NPR)-A or NPR-B: Guanylyl Cyclase-Linked Natri
Agonists at Opioid Receptors Spin the Wheels to Keep the Action Going
H3 Autoreceptors Modulate Histamine Synthesis through Calcium/Calmodulin- and cAMP-Dependent Protein Kinase Pathways
Gene Transfer of Cocaine Hydrolase Suppresses Cardiovascular Responses to Cocaine in Rats
Antitumor Activity of Methoxymorpholinyl Doxorubicin: Potentiation by Cytochrome P450 3A Metabolism
Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1)
Relaxin-3/Insulin-Like Peptide 5 Chimeric Peptide, a Selective Ligand for G Protein-Coupled Receptor (GPCR)135 and GPCR142 over Leucine-Rich Repeat-Containing
Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4
Protein Kinase C and Epidermal Growth Factor Stimulation of Raf1 Potentiates Adenylyl Cyclase Type 6 Activation in Intact Cells
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2005年第67卷第2期
Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells
The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase C-Dependent Mechanism
Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect of Insulin
Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney
Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers
Picrotoxin Accelerates Relaxation of GABAC Receptors
Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmaleimide-Sensitive Fa
Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhancer
Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein
Membrane Structure Modulation, Protein Kinase C Activation, and Anticancer Activity of Minerval
Inhibition of L-Type Cav1.2 Ca2+ Channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl
Transport of Bile Acids, Sulfated Steroids, Estradiol 17--D-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)
Negative Regulation of TRPC3 Channels by Protein Kinase C-Mediated Phosphorylation of Serine 712
Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking
N3-Methyladenine Induces Early Poly(ADP-Ribosylation), Reduction of Nuclear Factor-B DNA Binding Ability, and Nuclear Up-Regulation of Telomerase Activity
A Multifunctional Aromatic Residue in the External Pore Vestibule of Na+ Channels Contributes to the Local Anesthetic Receptor
P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Ho
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2005年第67卷第3期
Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D2 Receptor CRTH2
An Orphan Receptor Adopted by a Family of Transmitters
Transfected 3- but Not 2-Adrenergic Receptors Regulate Cystic Fibrosis Transmembrane Conductance Regulator Activity via a New Pathway Involving the Mitogen-Ac
Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization
Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4
Urinary Trypsin Inhibitor Protects against Systemic Inflammation Induced by Lipopolysaccharide
Constitutive Expression of Peroxisome Proliferator-Activated Receptor -Regulated Genes in Dwarf Mice
Functional Characterization of Go Signaling through G Protein-Regulated Inducer of Neurite Outgrowth 1
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties
PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2
Activators of Cation Channels: Potential in Treatment of Channelopathies
The Nongenotropic Synthetic Ligand 4-Estren-317-diol Is a High-Affinity Genotropic Androgen Receptor Agonist
A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
Macrophage Inflammatory Protein 2 Inhibits -Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kin
Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor /Retinoid X Receptor Pathway
Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors
Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors
Activation of the Melastatin-Related Cation Channel TRPM3 by D-erythro-Sphingosine
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2005年第67卷第4期
Pharmacological Differences between Human and Guinea Pig Histamine H1 Receptors: Asn84 (2.61) as Key Residue within an Additional Binding Pocket in the H1 Rec
Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell-Penetrating Peptide Technologies and Pharmacologies
Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Propertie
Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2
Molecular Determinants of the Agonist Binding Domain of a P2X Receptor Channel
Phosphatidylinositol-4,5-bisphosphate: Actin Dynamics and the Regulation of ATP-Dependent and -Independent Secretion
Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH) Receptors Determin
Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env
TRPV1b, a Functional Human Vanilloid Receptor Splice Variant
Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry
A Novel Class of Fusion Polypeptides Inhibits Exocytosis
Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functions
N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and Stress-Activated Ki
Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smoot
Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives
Involvement of Gi/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTP and PTP in Living Cells
Differential Sensitivity of Kir2 Inward-Rectifier Potassium Channels to a Mitochondrial Uncoupler: Identification of a Regulatory Site
Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells
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2005年第67卷第5期
Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3 Inhibition, and Viral Replication: A Scre
Adenosine in Tissue Protection and Tissue Regeneration
Palmitoylation of the 5-Hydroxytryptamine4a Receptor Regulates Receptor Phosphorylation, Desensitization, and -Arrestin-Mediated Endocytosis
Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2‘,4‘-Dihydroxy-6‘-methoxy-3‘,5‘-dimethylchalcone), a
Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of
Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4‘-Trimethoxystilbene
Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular
Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase
-Adrenergic Receptor Stimulation Promotes Gs Internalization through Lipid Rafts: A Study in Living Cells
Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine
Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
Isoflurane Induces a Protein Kinase C -Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
From Plants to Man: The GPCR “Tree of Life“
Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity in Vitro and i
Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus niva
Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors
Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors
The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis
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2005年第67卷第6期
The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress
What‘s for Lunch at the Conformational Cafeteria
Differential Spatial Approximation between Cholecystokinin Residue 30 and Receptor Residues in Active and Inactive Conformations
Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2
Endoplasmic Reticulum Stress Links Dyslipidemia to Inhibition of Proteasome Activity and Glucose Transport by HIV Protease Inhibitors
Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene
Retinoids Potentiate Peroxisome Proliferator-Activated Receptor Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myelo
Functional Interactions Between Nucleotide Binding Domains and Leukotriene C4 Binding Sites of Multidrug Resistance Protein 1 (ABCC1)
Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Recepto
Mutation of the DRY Motif Reveals Different Structural Requirements for the CC Chemokine Receptor 5-Mediated Signaling and Receptor Endocytosis
The Effects of Subunit Composition on the Inhibition of Nicotinic Receptors by the Amphipathic Blocker 2,2,6,6-Tetramethylpiperidin-4-yl Heptanoate
Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-1 Elimination
Centaurin-1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits 2-Adrenoceptor Internalization
Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
Expression of Nigrostriatal 6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by 3 Subunit Gene Deletion
Chemically Distinct Ligands Promote Differential CB1 Cannabinoid Receptor-Gi Protein Interactions
Neurotensin Stimulates Interleukin-8 Expression through Modulation of IB Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase C
DNA Methylation-Related Chromatin Modification in the Regulation of Mouse -Opioid Receptor Gene
Expression of Native 34 Neuronal Nicotinic Receptors: Binding and Functional Studies Investigating Turnover of Surface and Intracellular Receptor Populations
Cell Cycle Signaling by Endothelin-1 Requires Src Nonreceptor Protein Tyrosine Kinase
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2006年第68卷第1期
Cysteine 2.59(89) in the Second Transmembrane Domain of Human CB2 Receptor Is Accessible within the Ligand Binding Crevice: Evidence for Possible CB2 Deviatio
A GPCR That Is Not “DRY“
Inhibition of T-Type Calcium Channels Protects Neurons from Delayed Ischemia-Induced Damage
Receptor Signaling and Endocytosis Are Differentially Regulated by Somatostatin Analogs
Akt Is Essential for Insulin Modulation of Amphetamine-Induced Human Dopamine Transporter Cell-Surface Redistribution
Cellular and Pharmacogenetics Foundation of Synergistic Interaction of Pemetrexed and Gemcitabine in Human NoneCSmall-Cell Lung Cancer Cells
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor -De
Ric-8 Enhances G Protein -Dependent Signaling in Response to -Binding Peptides in Intact Cells
The RXR-Type Endoplasmic Reticulum-Retention/Retrieval Signal of GABAB1 Requires Distant Spacing from the Membrane to Function
Possible Involvement of CPI-17 in Augmented Bronchial Smooth Muscle Contraction in Antigen-Induced Airway Hyper-Responsive Rats
GABAA Receptor-Associated Protein Regulates GABAA Receptor Cell-Surface Number in Xenopus laevis Oocytes
Analysis of the In Vivo Functions of Mrp3
Distinct Structural Features of Phospholipids Differentially Determine Ethanol Sensitivity and Basal Function of BK Channels
Nanomolar and Micromolar Effects of 15-Deoxy-12,14-prostaglandin J2 on Amnion-Derived WISH Epithelial Cells: Differential Roles of Peroxisome Proliferator-Act
Modulation of Peroxisome Proliferator-Activated Receptor Activity Affects Neural Cell Adhesion Molecule and Polysialyltransferase ST8SiaIV Induction by Terat
Carboxyl Tail Cysteine Mutants of the Thyrotropin-Releasing Hormone Receptor Type 1 Exhibit Constitutive Signaling: Role of Palmitoylation
Influence of the Membrane Lipid Structure on Signal Processing via G Protein-Coupled Receptors
Hormonal Regulation of Hepatic Organic Anion Transporting Polypeptides
Erection Capability Is Potentiated by Long-Term Sildenafil Treatment: Role of Blood Flow-Induced Endothelial Nitric-Oxide Synthase Phosphorylation
Intragenic Suppression of Trafficking-Defective KCNH2 Channels Associated with Long QT Syndrome
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2006年第68卷第2期
The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate
Molecular Pharmacology of the Interaction of Anthracyclines with Iron
Arsenite-Induced Aryl Hydrocarbon Receptor Nuclear Translocation Results in Additive Induction of Phase I Genes and Synergistic Induction of Phase II Genes
Single Mutations at Asn295 and Leu305 in the Cytoplasmic Half of Transmembrane -Helix Domain 7 of the AT1 Receptor Induce Promiscuous Agonist Specificity for
Agonist-Induced Interactions between Angiotensin AT1 and Epidermal Growth Factor Receptors
Spatial Orientation of the Antagonist Granisetron in the Ligand-Binding Site of the 5-HT3 Receptor
Chemotherapy Compounds in Cervical Cancer Cells Primed by Reconstitution of p53 Function after Short Interfering RNA-Mediated Degradation of Human Papillomavi
Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Variants
Identification of Indole Derivatives Exclusively Interfering with a G Protein-Independent Signaling Pathway of the Prostaglandin D2 Receptor CRTH2
A Pregnane X Receptor Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development
Down-Regulation of Na+/Ca2+ Exchanger by Fluvastatin in Rat Cardiomyoblast H9c2 Cells: Involvement of RhoB in Na+/Ca2+ Exchanger mRNA Stability
cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to D-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo: Role of 1-Adrenoce
How the Monoamine Transporter Garden Grows
Expression Profiling of ABC Transporters in a Drug-Resistant Breast Cancer Cell Line Using AmpArray
Integrin Engagement Increases Histone H3 Acetylation and Reduces Histone H1 Association with DNA in Murine Lung Endothelial Cells
Orphanin FQ/Nociceptin Potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-EnkephalineCInduced eOpioid Receptor Phosphorylation
Single Nucleotide Polymorphisms in the Human Norepinephrine Transporter Gene Affect Expression, Trafficking, Antidepressant Interaction, and Protein Kinase C
Long-Term Morphine Treatment Enhances Proteasome-Dependent Degradation of G in Human Neuroblastoma SH-SY5Y Cells: Correlation with Onset of Adenylate Cyclase
Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Affect Allosteric Ca2+ Activation of the 42 Nicotinic Acetylcholine Receptor
Kahalalide F Induces Necrosis-Like Cell Death that Involves Depletion of ErbB3 and Inhibition of Akt Signaling
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2006年第68卷第3期
Down-Regulation of DNA Topoisomerase II Leads to Prolonged Cell Cycle Transit in G2 and Early M Phases and Increased Survival to Microtubule-Interacting Agent
Can a GDP-Liganded G-Protein Be Active
Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant
The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A
Enhanced CCAAT/Enhancer-Binding Protein -Liver-Enriched Inhibitory Protein Production by Oltipraz, Which Accompanies CUG Repeat-Binding Protein-1 (CUGBP1) RNA
Thromboxane A2 Promotes Interleukin-6 Biosynthesis Mediated by an Activation of Cyclic AMP-Response Element-Binding Protein in 1321N1 Human Astrocytoma Cells
Capsaicin Regulates Voltage-Dependent Sodium Channels by Altering Lipid Bilayer Elasticity
HIV Protease Inhibitors Activate the Unfolded Protein Response in Macrophages: Implication for Atherosclerosis and Cardiovascular Disease
The Role of Protein Synthesis and Degradation in the Post-Transcriptional Regulation of Rat Multidrug Resistance-Associated Protein 2 (Mrp2, Abcc2)
A Rapid New Assay to Detect RNA Editing Reveals Antipsychotic-Induced Changes in Serotonin-2C Transcripts
Guanine Nucleotide Exchange-Independent Activation of Gs Protein by 2-Adrenoceptor
The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target
Poly(C) Binding Protein Family Is a Transcription Factor in e?Opioid Receptor Gene Expression
Decrease in 3/6 Nicotinic Receptors but Not Nicotine-Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage
Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepat
Mechanism of Inhibition of TRPC Cation Channels by 2-Aminoethoxydiphenylborane
Pharmacological Telomerase Inhibition Can Sensitize Drug-Resistant and Drug-Sensitive Cells to Chemotherapeutic Treatment
Novel Plant Substances Acting as Subunit Isoform-Selective Positive Allosteric Modulators of GABAA Receptors
Norepinephrine Induces Lipolysis in 1/2/3-Adrenoceptor Knockout Mice
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2006年第68卷第4期
Reactive Oxygen Species Elicit Apoptosis by Concurrently Disrupting Topoisomerase II and DNA-Dependent Protein Kinase
Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
Structural Basis for Competition between Drug Binding and Kv1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels
Nitric Oxide Donors Induce Neurotrophin-Like Survival Signaling and Protect Neurons against Apoptosis
Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids
Human Hepatobiliary Transport of Organic Anions Analyzed by Quadruple-Transfected Cells
Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D1 Receptor Agonists
N-Methyl-N‘-nitro-N-nitrosoguanidine Activates Cell-Cycle Arrest through Distinct Mechanisms Activated in a Dose-Dependent Manner
Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-A
Overexpression of Rad23 Confers Resistance to Methylmercury in Saccharomyces cerevisiae via Inhibition of the Degradation of Ubiquitinated Proteins
Interaction of Bivalent Ligand KDN21 with Heterodimeric - Opioid Receptors in Human Embryonic Kidney 293 Cells
Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway
Activation of Mitogen-Activated Protein Kinases by Peroxisome Proliferator-Activated Receptor Ligands: An Example of Nongenomic Signaling
Mechanism of the Insulin-Releasing Action of -Ketoisocaproate and Related -Keto Acid Anions
Sialylation of Human Thyrotropin Receptor Improves and Prolongs Its Cell-Surface Expression
Characteristics of Ginsenoside Rg3-Mediated Brain Na+ Current Inhibition
Morphine-Induced e?Opioid Receptor Desensitization
Interaction between the 90-kDa Heat Shock Protein and Soluble Guanylyl Cyclase: Physiological Significance and Mapping of the Domains Mediating Binding
Icilin Activates the -Subunit of the Human Epithelial Na+ Channel
Principles of N-Methyl-D-aspartate Receptor Allosteric Modulation
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2006年第68卷第5期
A Prodrug of Cysteine, L-2-Oxothiazolidine-4-carboxylic Acid, Regulates Vascular Permeability by Reducing Vascular Endothelial Growth Factor Expression in Ast
Live Long and Prosper
Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel Small Molecule Formylpeptide Receptor Antagonists
RNA Interference against Human Papillomavirus Oncogenes in Cervical Cancer Cells Results in Increased Sensitivity to Cisplatin
Src Family Kinase Activity Is Required for Murine Embryonic Stem Cell Growth and Differentiation
Comparative Models of GABAA Receptor Extracellular and Transmembrane Domains: Important Insights in Pharmacology and Function
Roscovitine Triggers Excitotoxicity in Cultured Granule Neurons by Enhancing Glutamate Release
Cigarette Smoke Activates Human Monocytes by an Oxidant-AP-1 Signaling Pathway: Implications for Steroid Resistance
Gq-Mediated Activation of c-Jun N-Terminal Kinase by the Gastrin-Releasing Peptide-Preferring Bombesin Receptor Is Inhibited upon Costimulation of the Gs-Coup
Large-Scale Analysis of Genes that Alter Sensitivity to the Anticancer Drug Tirapazamine in Saccharomyces cerevisiae
Mice Lacking the 4 Nicotinic Receptor Subunit Fail to Modulate Dopaminergic Neuronal Arbors and Possess Impaired Dopamine Transporter Function
Presynaptic Inhibition via a Phospholipase C- and Phosphatidylinositol Bisphosphate-Dependent Regulation of Neuronal Ca2+ Channels
Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors
Interaction of Organic Cations with a Newly Identified Plasma Membrane Monoamine Transporter
Role of the Redox Protein Thioredoxin in Cytoprotective Mechanism Evoked by (-)-Deprenyl
Alkylation of -Tubulin on Glu 198 by a Microtubule Disrupter
Scavenger Receptors on Sinusoidal Liver Endothelial Cells Are Involved in the Uptake of Aldehyde-Modified Proteins
RIC-3 Enhances Functional Expression of Multiple Nicotinic Acetylcholine Receptor Subtypes in Mammalian Cells
Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism
Analysis of Human Multidrug Resistance Protein 1 (ABCC1) by Matrix-Assisted Laser Desorption Ionization/Time of Flight Mass Spectrometry: Toward Identificatio
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2006年第68卷第6期
Sulfotransferase (SULT) 1A1 Polymorphic Variants *1, *2, and *3 Are Associated with Altered Enzymatic Activity, Cellular Phenotype, and Protein Degradation
The Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Circadian Rhythms, Quiescence, and Expression of Clock Genes in Murine He
G12/13- and Rho-Dependent Activation of Phospholipase C- by Lysophosphatidic Acid and Thrombin Receptors
The Suramin Analog 4,4‘,4‘‘,4‘‘‘-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X3 Recepto
Ultrasound Stimulates Cyclooxygenase-2 Expression and Increases Bone Formation through Integrin, Focal Adhesion Kinase, Phosphatidylinositol 3-Kinase, and Akt
Modulation by LL-37 of the Responses of Salivary Glands to Purinergic Agonists
In Vitro and in Vivo Nuclear Factor-B Inhibitory Effects of the Cell-Penetrating Penetratin Peptide
Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant 122 GABAA Receptors
Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1
Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine
The Interaction of an Impermeant Cation with the Sheep Cardiac RyR Channel Alters Ryanoid Association
Distinct Receptor Activity-Modifying Protein Domains Differentially Modulate Interaction with Calcitonin Receptors
Potentiation of Native and Recombinant P2X7-Mediated Calcium Signaling by Arachidonic Acid in Cultured Cortical Astrocytes and Human Embryonic Kidney 293 Cell
Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways
T-Type Calcium Channels Are Inhibited by Fluoxetine and Its Metabolite Norfluoxetine
A Constitutively Active Hypoxia-Inducible Factor-1/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene
2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine Is a Novel Potent Competitive Antagonist of Human Neuronal 42 nAChRs
Suppression of the Phosphorylation of Receptor Tyrosine Phosphatase- on the Src-Independent Site Tyrosine 789 by Reactive Oxygen Species
Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with μ Conotoxin Binding Sites
A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes
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2006年第68卷第7期
Phosducin and Phosducin-like Protein Attenuate G-Protein-Coupled Receptor-Mediated Inhibition of Voltage-Gated Calcium Channels in Rat Sympathetic Neurons
The Aryl Hydrocarbon Receptor Signaling Pathway Is Modified through Interactions with a Kelch Protein
Agonist-Induced Cell Surface Trafficking of an Intracellularly Sequestered D1 Dopamine Receptor Homo-Oligomer
Receptor Regulation of Gene Expression of Axon Guidance Molecules: Implications for Adaptation
Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines
A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells
Potentiation of Acetylcholine Receptors by Divalent Cations
Correction to “No Nitric Oxide for HO-1 from Sodium Nitroprusside“
A Boronic-Chalcone Derivative Exhibits Potent Anticancer Activity through Inhibition of the Proteasome
Peroxisome Proliferator-Activated Receptor- and Retinoic Acid X Receptor Represses the TGF1 Gene via PTEN-Mediated p70 Ribosomal S6 Kinase-1 Inhibition: Role
Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB1 Cannabinoid Receptor
Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae
Neuroprotective Effects of 17-Estradiol and Nonfeminizing Estrogens against H2O2 Toxicity in Human Neuroblastoma SK-N-SH Cells
Reducing and Oxidizing Agents Sensitize Heat-Activated Vanilloid Receptor (TRPV1) Current
Experimental and Modeling Studies of Desensitization of P2X3 Receptors
Inhibition of Human Tyrosyl-DNA Phosphodiesterase by Aminoglycoside Antibiotics and Ribosome Inhibitors
Transfection of Drug-Specific T-Cell Receptors into Hybridoma Cells: Tools to Monitor Drug Interaction with T-Cell Receptors and Evaluate Cross-Reactivity to
Modification and Uptake of a Cisplatin Carbonato Complex by Jurkat Cells
Subtype Specificity of Scorpion -Toxin Tz1 Interaction with Voltage-Gated Sodium Channels Is Determined by the Pore Loop of Domain 3
Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane R
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2006年第68卷第8期
Capacitative and 1-Oleyl-2-acetyl-sn-glycerol-Activated Ca2+ Entry Distinguished Using Adenylyl Cyclase Type 8
42 Nicotinic Receptors with High and Low Acetylcholine Sensitivity: Pharmacology, Stoichiometry, and Sensitivity to Long-Term Exposure to Nicotine
Divergent Activities of Human Glutathione Transferases in the Bioactivation of Azathioprine
Interaction Studies of Multiple Binding Sites on M4 Muscarinic Acetylcholine Receptors
Cross-Talk between Gs- and Gq-Coupled Pathways in Regulation of Interleukin-4 by A2B Adenosine Receptors in Human Mast Cells
State-Dependent Verapamil Block of the Cloned Human Cav3.1 T-Type Ca2+ Channel
Mechanisms of Cardiolipin Oxidation by Cytochrome c: Relevance to Pro- and Antiapoptotic Functions of Etoposide
Validation of the Anti-Inflammatory Properties of Small-Molecule IB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Nega
Simultaneous Activation of the Opioid Receptor (OR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal
Agonist-Selective Mechanisms of μ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells
Allosteric Interactions Required for High-Affinity Binding of Dihydropyridine Antagonists to CaV1.1 Channels Are Modulated by Calcium in the Pore
Differences in Kinetics of Xanomeline Binding and Selectivity of Activation of G Proteins at M1 and M2 Muscarinic Acetylcholine Receptors
The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kill
Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice
Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression
A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Mo
Oligomerization of Recombinant and Endogenously Expressed Human Histamine H4 Receptors
OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells
Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor
Mapping Residues in the Ligand-Binding Domain of the 5-HT3 Receptor onto d-Tubocurarine Structure
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2006年第68卷第9期
Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor
Prolonged Recovery Rate of CB1 Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration
Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [3H]Norepinephrine Release from Mouse Hippocampal Synaptosomes
Hexachlorophene Inhibits Wnt/-Catenin Pathway by Promoting Siah-Mediated -Catenin Degradation
Deletion of the 7, 2, or 4 Nicotinic Receptor Subunit Genes Identifies Highly Expressed Subtypes with Relatively Low Affinity for [3H]Epibatidine
Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor
A Molecular Mechanism of Pyruvate Protection against Cytotoxicity of Reactive Oxygen Species in Osteoblasts
Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1/ and DNA Methylation
Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2‘,3‘-Substituted Purine- and Pyrimidine Nucleotide Inhibitors
Phospholipase C-3 and -1 Form Homodimers, but Not Heterodimers, through Catalytic and Carboxyl-Terminal Domains
Purine Release from Spinal Cord Microglia after Elevation of Calcium by Glutamate
Mutagenesis within Helix 6 of the Human 1-Adrenergic Receptor Identifies Lysine324 as a Residue Involved in Imparting the High-Affinity Binding State of Agoni
Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mo
Target Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and
Functional Analysis of the Extracellular Cysteine Residues in the Human Organic Anion Transporting Polypeptide, OATP2B1
Varenicline Is a Partial Agonist at 42 and a Full Agonist at 7 Neuronal Nicotinic Receptors
Negative Regulation of Superoxide Dismutase-1 Promoter by Thyroid Hormone
Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling
Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
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2006年第68卷第10期
The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with G12 but Not G13
Sazetidine-A, A Novel Ligand That Desensitizes 4β2 Nicotinic Acetylcholine Receptors without Activating Them
Ras-Dependent Recruitment of c-Myc for Transcriptional Activation of Nucleophosmin/B23 in Highly Malignant U1 Bladder Cancer Cells
S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial C
Inhibition of Ca2+ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca2+ Depletion and Cell Death in Leukemia Cells
17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30
Point Mutations in Either Subunit of the GABAB Receptor Confer Constitutive Activity to the Heterodimer
JX401, A p38 Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin
Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ahb-1 Receptor in the Presence and Absence of Liga
β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic 6* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines
Incorporation of the β3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors
Liver X Receptor (LXR)-β Regulation in LXR-Deficient Mice: Implications for Therapeutic Targeting
Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
Biophysical Characterization of the New Human Ether-A-Go-Go-Related Gene Channel Opener NS3623 [N-(4-Bromo-2-(1H-tetrazol-5-yl)-phenyl)-N‘-(3‘-trifluoromethyl
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism
Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression
Regulation of Mouse Hepatic -Amino-β-Carboxymuconate--Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by
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2006年第68卷第11期
A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads
A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiest
Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IB Kinase/Nuclear Factor-B Path
Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer
Nerve Growth Factor Regulates Adrenergic Expression
Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding
Inhibitory Gating Modulation of Small Conductance Ca2+-Activated K+ Channels by the Synthetic Compound (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtyla
Voltage-Dependent Block of N-Methyl-D-aspartate Receptors by Dopamine D1 Receptor Ligands
A Critical Role for the Short Intracellular C Terminus in Receptor Activity-Modifying Protein Function
Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
Modification of OATP2B1-Mediated Transport by Steroid Hormones
Corticostriatal Up-Regulation of Activity-Regulated Cytoskeletal-Associated Protein Expression after Repeated Exposure to Cocaine
Involvement of Tissue Plasminogen Activator-Plasmin System in Depolarization-Evoked Dopamine Release in the Nucleus Accumbens of Mice
Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug
Adenylyl Cyclase 6 Overexpression Decreases the Permeability of Endothelial Monolayers via Preferential Enhancement of Prostacyclin Receptor Function
Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia
Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4 Requires Coactivators Peroxisomal Proliferator Activated Receptor- Coa
Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside
Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content
Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling
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2006年第68卷第12期
The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice
Neurotoxicity of Domoic Acid in Cerebellar Granule Neurons in a Genetic Model of Glutathione Deficiency
The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma
Endogenous Hepatic Expression of the Hepatitis B Virus X-Associated Protein 2 Is Adequate for Maximal Association with Aryl Hydrocarbon Receptor-90-kDa Heat S
Analysis of the Dissociated Steroid RU24858 Does Not Exclude a Role for Inducible Genes in the Anti-Inflammatory Actions of Glucocorticoids
YM-244769, a Novel Na+/Ca2+ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal
Methamphetamine-Induced Sensitization Differentially Alters pCREB and FosB throughout the Limbic Circuit of the Mammalian Brain
The Mechanism of Activity-Dependent Sodium Channel Inhibition by the Antidepressants Fluoxetine and Desipramine
Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats
Role of the Agonist Binding Site in Up-Regulation of Neuronal Nicotinic 42 Receptors
Point Mutations in the Transmembrane Region of GABAB2 Facilitate Activation by the Positive Modulator N,N‘-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4
2,3-Butanedione Monoxime Affects Cystic Fibrosis Transmembrane Conductance Regulator Channel Function through Phosphorylation-Dependent and Phosphorylation-In
Essential Role of C-Rel in Nitric-Oxide Synthase-2 Transcriptional Activation: Time-Dependent Control by Salicylate
cAMP Inhibits Transforming Growth Factor--Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Card
Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine:
Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hy
Molecular Interaction of Serotonin 5-HT2A Receptor Residues Phe339(6.51) and Phe340(6.52) with Superpotent N-Benzyl Phenethylamine Agonists
Eriocalyxin B Inhibits Nuclear Factor-B Activation by Interfering with the Binding of Both p65 and p50 to the Response Element in a Noncompetitive Manner
Insights into the Cholecystokinin 2 Receptor Binding Site and Processes of Activation
Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver
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2007年第69卷第1期
Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP
Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis
c-Abl Kinase Regulates Curcumin-Induced Cell Death through Activation of c-Jun N-Terminal Kinase
Characterization of 2-Adrenergic Receptor Dephosphorylation: Comparison with the Rate of Resensitization
Response to Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor“
Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor“
Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors
Translational Regulation of Rat Multidrug Resistance-Associated Protein 2 Expression Is Mediated by Upstream Open Reading Frames in the 5‘ Untranslated Region
An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis
Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands
Geldanamycin Interferes with the 90-kDa Heat Shock Protein, Affecting Lipopolysaccharide-Mediated Interleukin-1 Expression and Apoptosis within Macrophages
Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translo
Short Polybasic Peptide Sequences Are Potent Inhibitors of PC5/6 and PC7: Use of Positional Scanning-Synthetic Peptide Combinatorial Libraries as a Tool for t
RasGRP1 Confers the Phorbol Ester-Sensitive Phenotype to EL4 Lymphoma Cells
Phosphorylation of G11 Protein Contributes to Agonist-Induced Desensitization of 5-HT2A Receptor Signaling
Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
Carbohydrate-Binding Agents Efficiently Prevent Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN)-Directed HIV-1 Transm
Characterization of the Tritium-Labeled Analog of L-threo--Benzyloxyaspartate Binding to Glutamate Transporters
Neurokinin 1 Receptors Trigger Overlapping Stimulation and Inhibition of CaV2.3 (R-Type) Calcium Channels
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2007年第69卷第2期
Imino Sugars Are Potent Agonists of the Human Glucose Sensor SGLT3
Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir
Inhibition of Tumor Necrosis Factor--Inducible Inflammatory Genes by Interferon- Is Associated with Altered Nuclear Factor-B Transactivation and Enhanced Hist
A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure
Unnatural Amino Acid-Substituted (Hydroxyethyl)urea Peptidomimetics Inhibit -Secretase and Promote the Neuronal Differentiation of Neuroblastoma Cells
Nefiracetam Potentiates N-Methyl-D-aspartate (NMDA) Receptor Function via Protein Kinase C Activation and Reduces Magnesium Block of NMDA Receptor
2-Aminoethoxydiphenyl Borate Directly Inhibits Channels Composed of Connexin26 and/or Connexin32
1,1-Bis(3‘-Indolyl)-1-(p-substitutedphenyl)methanes Inhibit Growth, Induce Apoptosis, and Decrease the Androgen Receptor in LNCaP Prostate Cancer Cells throug
An Opioid Agonist that Does Not Induce μ-Opioid Receptor-Arrestin Interactions or Receptor Internalization
Tonically Active GABAA Receptors in Hippocampal Pyramidal Neurons Exhibit Constitutive GABA-Independent Gating
Stabilization of Cellular mRNAs and Up-Regulation of Proteins by Oligoribonucleotides Homologous to the Bcl2 Adenine-Uridine Rich Element Motif
Involvement of Dopamine System in Regulation of Na+,K+-ATPase in the Striatum upon Activation of Opioid Receptors by Morphine
Pharmacology and Signaling Properties of Epidermal Growth Factor Receptor Isoforms Studied by Bioluminescence Resonance Energy Transfer
Kinins Promote B2 Receptor Endocytosis and Delay Constitutive B1 Receptor Endocytosis
Agonist-, Antagonist-, and Benzodiazepine-Induced Structural Changes in the 1 Met113-Leu132 Region of the GABAA Receptor
The Synthetic Androgen Methyltrienolone (R1881) Acts as a Potent Antagonist of the Mineralocorticoid Receptor
Ethanol Modulates the Interaction of the Endogenous Neurosteroid Allopregnanolone with the 122L GABAA Receptor
Nordihydroguaiaretic Acid Affects Multiple Dynein-Dynactin Functions in Interphase and Mitotic Cells
Analysis of In Vivo Nuclear Factor-B Activation during Liver Inflammation in Mice: Prevention by Catalase Delivery
RanGAP-Mediated Nuclear Protein Import in Vascular Smooth Muscle Cells Is Augmented by Lysophosphatidylcholine
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2007年第69卷第3期
Role of Nuclear Factor-B and Protein Kinase C Signaling in the Expression of the Kinin B1 Receptor in Human Vascular Smooth Muscle Cells
ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1 (HIF-1) Binding and Mediates HIF-1 Expression by Bafilomycin A1
Activation of the CXCR3 Chemokine Receptor through Anchoring of a Small Molecule Chelator Ligand between TM-III, -IV, and -VI
Molecular Interactions Underlying the Unusually High Adenosine Affinity of a Novel Trypanosoma brucei Nucleoside Transporter
Essential Role for Class II Phosphoinositide 3-kinase -Isoform in Ca2+-Induced, Rho- and Rho Kinase-Dependent Regulation of Myosin Phosphatase and Contraction
Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kine
Probing HIV-1 Integrase Inhibitor Binding Sites with Position-Specific Integrase-DNA Cross-Linking Assays
The Effects of Central Nervous System-Active Valproic Acid Constitutional Isomers, Cyclopropyl Analogs, and Amide Derivatives on Neuronal Growth Cone Behavior
4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est-Like Protein-1-Activating Protein-1 Sign
Up-Regulation of 150-kDa Oxygen-Regulated Protein by Celecoxib in Human Gastric Carcinoma Cells
Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital
The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells
Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca2+/Calmodulin-Dependent Kinase II-Dependent Mechanism
Characterization and Comparison of Nicotine and Cotinine Metabolism in Vitro and in Vivo in DBA/2 and C57BL/6 Mice
Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice
Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation
Evidence for Direct Regulation of Myocardial Na+/H+ Exchanger Isoform 1 Phosphorylation and Activity by 90-kDa Ribosomal S6 Kinase (RSK): Effects of the Novel
Pioglitazone Inhibits Androgen Production in NCI-H295R Cells by Regulating Gene Expression of CYP17 and HSD3B2
Novel G423S Mutation of Human 7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism
Ca2+ Permeability of the (4)3(2)2 Stoichiometry Greatly Exceeds That of (4)2(2)3 Human Acetylcholine Receptors
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2007年第69卷第4期
Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5‘-O-(3-[35S]thio)triphosphate Binding S
Genetic Evidence for a Protective Role of Heat Shock Factor 1 against Irritant-Induced Gastric Lesions
An Essential Role for Constitutive Endocytosis, but Not Activity, in the Axonal Targeting of the CB1 Cannabinoid Receptor
Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyot
The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State
Constitutive Trafficking-More Than Just Running in Circles?
Interaction of Gq and Kir3, G Protein-Coupled Inwardly Rectifying Potassium Channels
Structure of the d(CGCGAATTCGCG)2 Complex of the Minor Groove Binding Alkylating Agent Alkamin Studied by Mass Spectrometry
Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression
In Vivo Regulation of Homer1a Expression in the Striatum by Cocaine
Structure-Based Identification of Novel Human -Glutamylcysteine Synthetase Inhibitors
Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral M
Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gi Signaling
Methylmercury-Induced Increase of Intracellular Ca2+ Increases Spontaneous Synaptic Current Frequency in Rat Cerebellar Slices
Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanos
Function of Both Sinusoidal and Canalicular Transporters Controls the Concentration of Organic Anions within Hepatocytes
Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca2+-Activated K+ Channel Activators Selective for 1 and 4 but Not for 2 Subunits
High-Throughput Screening for Small-Molecule Activators of Neutrophils: Identification of Novel N-Formyl Peptide Receptor Agonists
BRCA1 Contributes to Cell Cycle Arrest and Chemoresistance in Response to the Anticancer Agent Irofulven
N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells
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2007年第69卷第5期
Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1
Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase
Quantitative Evaluation of Human Opioid Receptor Desensitization Using the Operational Model of Drug Action
Activation of Single Nicotinic Receptor Channels from Caenorhabditis elegans Muscle
PAR1, but Not PAR4, Activates Human Platelets through a Gi/o/Phosphoinositide-3 Kinase Signaling Axis
Interaction of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 with the Negative Allosteric Antagonist Site Is Required for Potentia
A Critical Role of Luteolin-Induced Reactive Oxygen Species in Blockage of Tumor Necrosis Factor-Activated Nuclear Factor-B Pathway and Sensitization of Apopt
Molecular Signalling Mediating the Protective Effect of A1 Adenosine and mGlu3 Metabotropic Glutamate Receptor Activation against Apoptosis by Oxygen/Glucose
Identification of a Second Blocker Binding Site at the Cytoplasmic Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore
Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist
Conformationally Sensitive Reactivity to Permeant Sulfhydryl Reagents of Cysteine Residues Engineered into Helical Hairpin 1 of the Glutamate Transporter GLT-
Real-Time Analysis of Agonist-Induced Activation of Protease-Activated Receptor 1/Gi1 Protein Complex Measured by Bioluminescence Resonance Energy Transfer in
Maternal Cocaine Administration Causes an Epigenetic Modification of Protein Kinase C Gene Expression in Fetal Rat Heart
Agonist-Driven Conformational Changes in the Inner -Sheet of 7 Nicotinic Receptors
Vitamin D3 Derivatives with Adamantane or Lactone Ring Side Chains are Cell Type-Selective Vitamin D Receptor Modulators
Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmac
Insulin Increases the Potency of Glycine at Ionotropic Glycine Receptors
Domains Necessary for G12 Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is G12 a Novel Regulatory Subunit of PP2A?
Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D-aspartate Receptors and Neuronal Nitric-Oxide Synthase
A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor- Activity
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2007年第69卷第6期
Pioglitazone and Rosiglitazone Decrease Prostaglandin E2 in Non–Small-Cell Lung Cancer Cells by Up-Regulating 15-Hydroxyprostaglandin Dehydrogenase
Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-B-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products t
The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells
The Amine-Containing Cutaneous Irritant Heptylamine Inhibits the Volume-Regulated Anion Channel and Mobilizes Intracellular Calcium in Normal Human Epidermal
Quercetin Activates an Angiogenic Pathway, Hypoxia Inducible Factor (HIF)-1-Vascular Endothelial Growth Factor, by Inhibiting HIF-Prolyl Hydroxylase: a Struct
Gq-Mediated Regulation of TASK3 Two-Pore Domain Potassium Channels: The Role of Protein Kinase C
Inhibition of Vascular Endothelial Growth Factor Cotranslational Translocation by the Cyclopeptolide CAM741
Subunit-Stoichiometric Evidence for Kir6.2 Channel Gating, ATP Binding, and Binding-Gating Coupling
Inhibition of Tumor Necrosis Factor- through Selective Blockade of Pre-mRNA Splicing by Shikonin
Identification and Functional Analysis of a Novel Human CYP2E1 Far Upstream Enhancer
The Relaxin Family Peptide Receptor 3 Activates Extracellular Signal-Regulated Kinase 1/2 through a Protein Kinase C-Dependent Mechanism
The Kinetics of Inhibition of Human Acetylcholinesterase and Butyrylcholinesterase by Two Series of Novel Carbamates
Involvement of a Dysfunctional Dopamine-D1/N-Methyl-D-aspartate-NR1 and Ca2+/Calmodulin-Dependent Protein Kinase II Pathway in the Impairment of Latent Learni
Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney
Natural and Enantiomeric Etiocholanolone Interact with Distinct Sites on the Rat 122L GABAA Receptor
2A Adrenergic Receptor Activation Inhibits Epileptiform Activity in the Rat Hippocampal CA3 Region
Pharmacology of -Conotoxin MII-Sensitive Subtypes of Nicotinic Acetylcholine Receptors Isolated by Breeding of Null Mutant Mice
Phosphatase and Tensin Homolog Deleted on Chromosome 10 Suppression Is an Important Process in Peroxisome Proliferator-Activated Receptor- Signaling in Adipoc
Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes
Mechanism of Thiazolidinedione-Dependent Cell Death in Jurkat T Cells
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2007年第69卷第7期
Chronic Intermittent Ethanol Treatment Selectively Alters N-Methyl-D-aspartate Receptor Subunit Surface Expression in Cultured Cortical Neurons
Small-Molecule Vasopressin-2 Receptor Antagonist Identified by a G-Protein Coupled Receptor “Pathway“ Screen
Characterization of the Novel Human Serotonin Receptor Subunits 5-HT3C,5-HT3D, and 5-HT3E
Vasoactive Intestinal Peptide Transactivates the Androgen Receptor through a Protein Kinase A-Dependent Extracellular Signal-Regulated Kinase Pathway in Prost
Antidiabetes and Antiobesity Effect of Cryptotanshinone via Activation of AMP-Activated Protein Kinase
Nigrostriatal Damage Preferentially Decreases a Subpopulation of 62* nAChRs in Mouse, Monkey, and Parkinson‘s Disease Striatum
Glycogen Synthase Kinase 3 Regulates N-Methyl-D-aspartate Receptor Channel Trafficking and Function in Cortical Neurons
Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Re
Serotonin Inhibits Neuronal Excitability by Activating Two-Pore Domain K+ Channels in the Entorhinal Cortex
Structure-Activity Relationship of 1,4-Dihydropyridines as Potentiators of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
Bioactivation of Nitroglycerin by Ascorbate
Activation of the Angiotensin II Type 1 Receptor Leads to Movement of the Sixth Transmembrane Domain: Analysis by the Substituted Cysteine Accessibility Metho
CCR5 Small-Molecule Antagonists and Monoclonal Antibodies Exert Potent Synergistic Antiviral Effects by Cobinding to the Receptor
Regulation of Cytochrome P450 2E1 under Hypertonic Environment through TonEBP in Human Hepatocytes
Hypoxia Inhibits Paclitaxel-Induced Apoptosis through Adenosine-Mediated Phosphorylation of Bad in Glioblastoma Cells
Inhibition of Transforming Growth Factor Signaling Reduces Pancreatic Adenocarcinoma Growth and Invasiveness
Cholesterol-Like Effects of Selective Cyclooxygenase Inhibitors and Fibrates on Cellular Membranes and Amyloid- Production
Identification and Characterization of a New Tubulin-Binding Tetrasubstituted Brominated Pyrrole
Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium
Adrenomedullin Stimulates Nitric Oxide Production from Primary Rat Hypothalamic Neurons: Roles of Calcium and Phosphatases
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2007年第69卷第8期
A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis
Structure-Function Studies of Allosteric Agonism at M2 Muscarinic Acetylcholine Receptors
Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor
Inhibition of Hypoxia-Induced Increase of Blood-Brain Barrier Permeability by YC-1 through the Antagonism of HIF-1 Accumulation and VEGF Expression
N-Ethylmaleimide-Sensitive Factor Regulates β2 Adrenoceptor Trafficking and Signaling in Cardiomyocytes
Suppression of Osteoclastogenesis by N,N-Dimethyl-D-erythro-sphingosine: A Sphingosine Kinase Inhibition-Independent Action
Glitazones Induce Astroglioma Cell Death by Releasing Reactive Oxygen Species from Mitochondria: Modulation of Cytotoxicity by Nitric Oxide
Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Hu
Multidrug Resistance Proteins 2 and 3 Provide Alternative Routes for Hepatic Excretion of Morphine-Glucuronides
Identification of the Atypical L-Type Ca2+ Channel Blocker Diltiazem and Its Metabolites As Ghrelin Receptor Agonists
5-Androstenediol Promotes Survival of -Irradiated Human Hematopoietic Progenitors through Induction of Nuclear Factor-B Activation and Granulocyte Colony-Stim
β1 (KCNMB1) Subunits Mediate Lithocholate Activation of Large-Conductance Ca2+-Activated K+ Channels and Dilation in Small, Resistance-Size Arteries
Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory
Critical Role for Sphingosine Kinase-1 in Regulating Survival of Neuroblastoma Cells Exposed to Amyloid-β Peptide
Molecular Interaction of a Potent Nonpeptide Agonist with the Chemokine Receptor CCR8
Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity
Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
Bradykinin-Induced Nuclear Factor of Activated T-Cells-Dependent Transcription in Rat Dorsal Root Ganglion Neurons
A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M2 Muscarinic Receptor
Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Se
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2007年第69卷第9期
The Multikinase Inhibitor Sorafenib Induces Apoptosis in Highly Imatinib Mesylate-Resistant Bcr/Abl+ Human Leukemia Cells in Association with Signal Transduce
Modulation of Presynaptic 3-Containing GABAA Receptors Limits the Immobilizing Actions of GABAergic Anesthetics
Signaling Pathways Involved in Cyclooxygenase-2 Induction by Hepatocyte Growth Factor in Non–Small-Cell Lung Cancer
Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10
Phosphorylation of Gs Influences Its Association with the μ-Opioid Receptor and Is Modulated by Long-Term Morphine Exposure
Perturbation of Dopamine Metabolism by 3-Amino-2-(4‘-halophenyl)propenes Leads to Increased Oxidative Stress and Apoptotic SH-SY5Y Cell Death
Functional Characterization of the Promoter of Human Carbonyl Reductase 1 (CBR1). Role of XRE Elements in Mediating the Induction of CBR1 by Ligands of the Ar
Thiazolidinediones Modulate the Expression of -Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of Skp1-Cul1-F-box Protein E3
Distinct Profiles of 7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Low-Dose BBR3610 Toxicity in Colon Cancer Cells Is p53-Independent and Enhanced by Inhibition of Epidermal Growth Factor Receptor (ERBB1)-Phosphatidyl Inosito
Stromal Cell-Derived Factor-1 Induces Matrix Metalloprotease-13 Expression in Human Chondrocytes
Interleukin-6 Alters the Cellular Responsiveness to Clopidogrel, Irinotecan, and Oseltamivir by Suppressing the Expression of Carboxylesterases HCE1 and HCE2
Apoptotic Action of Peroxisome Proliferator-Activated Receptor- Activation in Human Non–Small-Cell Lung Cancer Is Mediated via Proline Oxidase-Induced Reactiv
Up-Regulation and Increased Activity of KV3.4 Channels and Their Accessory Subunit MinK-Related Peptide 2 Induced by Amyloid Peptide Are Involved in Apoptotic
Exacerbation of Dopaminergic Terminal Damage in a Mouse Model of Parkinson‘s Disease by the G-Protein-Coupled Receptor Protease-Activated Receptor 1
The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents
A New Steroid Derivative Stabilizes G-Quadruplexes and Induces Telomere Uncapping in Human Tumor Cells
Interactions with Filamin A Stimulate Surface Expression of Large-Conductance Ca2+-Activated K+ Channels in the Absence of Direct Actin Binding
A Key Role for Diacylglycerol Lipase- in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization
The Human UDP-Glucuronosyltransferase: Identification of Key Residues within the Nucleotide-Sugar Binding Site
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2007年第69卷第10期
Disruption of Oligomerization Induces Nucleocytoplasmic Shuttling of Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor
Antithrombotic Effect of a Protein-Type I Class Snake Venom Metalloproteinase, Kistomin, Is Mediated by Affecting Glycoprotein Ib-von Willebrand Factor Intera
Pharmacological Characterization of a Novel Nonpeptide Antagonist for Formyl Peptide Receptor-Like 1
Effect of Breast Cancer Resistance Protein (Bcrp/Abcg2) on the Disposition of Phytoestrogens
Aryl Hydrocarbon Receptor Splice Variants in the Dioxin-Resistant Rat: Tissue Expression and Transactivational Activity
Physiological Differences between Human and Rat Primary Hepatocytes in Response to Liver X Receptor Activation by 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(
Gemfibrozil Ameliorates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Independent of Peroxisome Proliferator-Activated Receptor-
Identification of Regions of the -1 Receptor Ligand Binding Site Using a Novel Photoprobe
Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-D-aspartate Glutamate Receptors
Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action
Serotonin 5-Hydroxytryptamine2C Receptor Signaling in Hypothalamic Proopiomelanocortin Neurons: Role in Energy Homeostasis in Females
Identification of a Bis-guanylhydrazone [4,4‘-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase
Application of β-Lactamase Enzyme Complementation to the High-Throughput Screening of Toll-Like Receptor Signaling Inhibitors
Activation of the Adenosine A1 Receptor Inhibits HIV-1 Tat-Induced Apoptosis by Reducing Nuclear Factor-B Activation and Inducible Nitric-Oxide Synthase
Insulin Facilitates the Hepatic Clearance of Plasma Amyloid β-Peptide (1–40) by Intracellular Translocation of Low-Density Lipoprotein Receptor-Related Protei
Structural Determinates for Apolipoprotein E-Derived Peptide Interaction with the 7 Nicotinic Acetylcholine Receptor
Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Acti
Live Cell Analysis of G Protein β5 Complex Formation, Function, and Targeting
Illuminating Gβ5 Signaling
Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?
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2007年第69卷第11期
Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of
Evidence for an Aryl Hydrocarbon Receptor-Mediated Cytochrome P450 Autoregulatory Pathway
Ligand-Directed Signaling at the 3-Adrenoceptor Produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) Re
Disruption of Clock Gene Expression Alters Responses of the Aryl Hydrocarbon Receptor Signaling Pathway in the Mouse Mammary Gland
Geranylgeranylacetone, an Inducer of the 70-kDa Heat Shock Protein (HSP70), Elicits Unfolded Protein Response and Coordinates Cellular Fate Independently of H
Inhibition of the Na+/Dicarboxylate Cotransporter by Anthranilic Acid Derivatives
The Neurosteroids Dehydroepiandrosterone Sulfate and Pregnenolone Sulfate Inhibit the UNC-49 GABA Receptor through a Common Set of Residues
Association of Nucleophosmin Negatively Regulates CXCR4-Mediated G Protein Activation and Chemotaxis
Role of Protein Kinase C and Its Adaptor Protein p62 in Voltage-Gated Potassium Channel Modulation in Pulmonary Arteries
Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 in Migration Signaling of a G
Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity
Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Bo
Inhibition of Trail Gene Expression by Cyclopentenonic Prostaglandin 15-Deoxy-12,14-Prostaglandin J2 in T Lymphocytes
Peroxisomal Proliferator-Activated Receptor- Protects Renal Tubular Cells from Doxorubicin-Induced Apoptosis
Enhancing Glutamate Transport: Mechanism of Action of Parawixin1, a Neuroprotective Compound from Parawixia bistriata Spider Venom
Mammalian Skeletal Muscle Voltage-Gated Sodium Channels Are Affected by Scorpion Depressant “Insect-Selective“ Toxins when Preconditioned
G Interferes with Ca2+-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex
Assessment of the Roles of Serines 5.43(239) and 5.46(242) for Binding and Potency of Agonist Ligands at the Human Serotonin 5-HT2A Receptor
Rational Engineering of Human Cytochrome P450 2B6 for Enhanced Expression and Stability: Importance of a Leu264Phe Substitution
Dimerization Region of Soluble Guanylate Cyclase Characterized by Bimolecular Fluorescence Complementation in Vivo
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2007年第69卷第12期
Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor-B Activation
Repression of T-Cell Function by Thionamides Is Mediated by Inhibition of the Activator Protein-1/Nuclear Factor of Activated T-Cells Pathway and Is Associate
Cystine-Glutamate Transporter SLC7A11 Mediates Resistance to Geldanamycin but Not to 17-(Allylamino)-17-demethoxygeldanamycin
Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 / and DNA Methylation
K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH2-Terminal Kinase 3 (JNK3
Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of -Catenin
Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase
Aspirin Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-
Inhibition of TRPP3 Channel by Amiloride and Analogs
Identification of the Substrate Binding Region of Vesicular Monoamine Transporter-2 (VMAT-2) Using Iodoaminoflisopolol as a Novel Photoprobe
CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a
Docosahexaenoic Acid Induces Increases in [Ca2+]i via Inositol 1,4,5-Triphosphate Production and Activates Protein Kinase C and - via Phosphatidylserine Bindi
The N-Terminal Domains of both NR1 and NR2 Subunits Determine Allosteric Zn2+ Inhibition and Glycine Affinity of N-Methyl-D-aspartate Receptors
The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels
Resveratrol (trans-3,5,4‘-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving A
Identification of a Postendocytic Sorting Sequence in CCR5
Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands
Transforming Growth Factor-1 Impairs Endothelin-1-Mediated Contraction of Brain Vessels by Inducing Mitogen-Activated Protein (MAP) Kinase Phosphatase-1 and I
Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer
A Dioxin-Responsive Enhancer 3‘ of the Human CYP1A2 Gene
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2008年第70卷第1期
Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein
Inhibition of Estrogen-Mediated Uterine Gene Expression Responses by Dioxin
Identification of a Novel Ligand Binding Residue Arg38(1.35) in the Human Gonadotropin-Releasing Hormone Receptor
The Differential Interactions of Peroxisome Proliferator-Activated Receptor Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities
High-Affinity Cation Binding to Organic Cation Transporter 1 Induces Movement of Helix 11 and Blocks Transport after Mutations in a Modeled Interaction Domain
Inhibition of TRPC5 Channels by Intracellular ATP
Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled 6 and β
High Mobility Group Protein B1 Is an Activator of Apoptotic Response to Antimetabolite Drugs
Identification of Key Residues Coordinating Functional Inhibition of P2X7 Receptors by Zinc and Copper
Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response
Genistein Induces Phenotypic Reversion of Endoglin Deficiency in Human Prostate Cancer Cells
The Unusual State-Dependent Affinity of P2X3 Receptors Can Be Explained by an Allosteric Two-Open-State Model
Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor- in Primary Rat Adipocytes
Long-Acting β2-Adrenoceptor Agonists Synergistically Enhance Glucocorticoid-Dependent Transcription in Human Airway Epithelial and Smooth Muscle Cells
17β-Estradiol Promotes Breast Cancer Cell Proliferation-Inducing Stromal Cell-Derived Factor-1-Mediated Epidermal Growth Factor Receptor Transactivation: Reve
Ahn S, Shenoy SK, Wei H, and Lefkowitz RJ (2004) Differential kinetic and spatial patterns of β-arrestin and G protein-mediated ERK activation by the angioten
β-Arrestin-Dependent μ-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK A
Enhancement of Glucose Transporter Expression of Brain Endothelial Cells by Vascular Endothelial Growth Factor Derived from Glioma Exposed to Hypoxia
The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels
Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities
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2008年第70卷第2期
Regulation of Human 3-Hydroxysteroid Dehydrogenase (AKR1C4) Expression by the Liver X Receptor
Efavirenz Accelerates HIV-1 Reverse Transcriptase Ribonuclease H Cleavage, Leading to Diminished Zidovudine Excision
Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?
3-Methylcholanthrene Displays Dual Effects on Estrogen Receptor (ER) and ERβ Signaling in a Cell-Type Specific Fashion
Mitogenic Effects of Cytokines on Smooth Muscle Are Critically Dependent on Protein Kinase A and Are Unmasked by Steroids and Cyclooxygenase Inhibitors
Methyl 2-Cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate Is a Peroxisome Proliferator-Activated Receptor- Agonist That Induces Receptor-Independent Apoptosis in
Functional Characterization of Bone Morphogenetic Protein Binding Sites and Smad1/5 Activation in Human Vascular Cells
Multiple Binding Sites for Substrates and Modulators of Semicarbazide-Sensitive Amine Oxidases: Kinetic Consequences
[3H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor
A Peroxisome Proliferator-Activated Receptor -Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon
Impact of Targeting the Adenine- and Uracil-Rich Element of bcl-2 mRNA with Oligoribonucleotides on Apoptosis, Cell Cycle, and Neuronal Differentiation in SHS
Reduced Expression of DNA Topoisomerase I in SF295 Human Glioblastoma Cells Selected for Resistance to Homocamptothecin and Diflomotecan
Structural Analog of Sildenafil Identified as a Novel Corrector of the F508del-CFTR Trafficking Defect
Cloning and Functional Expression of a Novel Gi Protein-Coupled Receptor for Adenine from Mouse Brain
Transport of Cisplatin by the Copper Efflux Transporter ATP7B
Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4 to the Proximal Pr
Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB1 and CB2
Role of Extracellular Domain Dimerization in Agonist-Induced Activation of Natriuretic Peptide Receptor A
BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines
Small Molecule Disruption of G Protein β Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation
更多>>
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2008年第70卷第3期
Direct Role of Streptozotocin in Inducing Thermal Hyperalgesia by Enhanced Expression of Transient Receptor Potential Vanilloid 1 in Sensory Neurons
A New Mechanism of 6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one Dihydrochloride (TAS-103) Action Discovered by Target Screening
N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor by Dehydroepiandrosterone and Other Peroxisome
Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the 4β3 GABAA Receptor
The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Fetal Distribution of Glyburide in the Pregnant Mouse: An Obstetric-Fetal Pharmacology Research Unit
State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+ Channel Isoforms by Ranolazine
Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induce
A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator
Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes
Identification of Oxysterol 7-Hydroxylase (Cyp7b1) as a Novel Retinoid-Related Orphan Receptor (ROR) (NR1F1) Target Gene and a Functional Cross-Talk between
Lipid Composition Alters Drug Action at the Nicotinic Acetylcholine Receptor
Plasticity of Adenylyl Cyclase-Related Signaling Sequelae after Long-Term Morphine Treatment
An Intracellular Allosteric Site for a Specific Class of Antagonists of the CC Chemokine G Protein-Coupled Receptors CCR4 and CCR5
Progesterone Receptor (PR) Isoforms PRA and PRB Differentially Regulate Expression of the Breast Cancer Resistance Protein in Human Placental Choriocarcinoma
Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution
The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine
Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors
Activity and Subcellular Trafficking of the Sodium-Coupled Choline Transporter CHT Is Regulated Acutely by Peroxynitrite
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